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Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. Venofer treatment may be repeated if necessary. The dosage of Venofer is expressed in mg of elemental iron. This site complies with the HONcode standard for trust- worthy health information: verify here. Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. Iron Deficit - Multi-Calc - GlobalRPH - Medical Calculators, Clinicians Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. The iron deficit estimation is based on the Ganzoni formula: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. You may need extra iron because of blood loss during kidney dialysis. Venofer treatment may be repeated if necessary. Use Caution/Monitor. Pain, swelling, or redness at the injection site may occur. Use Caution/Monitor. Applies only to oral form of both agents. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. *Administer early during the dialysis session. Applies only to oral form of both agents. Use Caution/Monitor. Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD): Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Use Caution/Monitor. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. Found in multiple references. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or Venofer® (iron sucrose) injection, USP is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Calculosaurus | Medical calculators for obstetrics and gynaecology Use the menu to browse through our clinical calculators. This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. Applies only to oral form of both agents. Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Reactions have occurred following the first dose or subsequent doses of Venofer. Dosing for patients who weigh 50 kg or more For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Koch TA, Myers J, Goodnough LT. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Administer while the patient is in a reclined or semi-reclined position. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Interaction only with oral iron administration. Applies only to oral form of both agents. David McAuley, Pharm.D. Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. iron sucrose decreases levels of ibandronate by inhibition of GI absorption. iron sucrose increases levels of calcium carbonate by enhancing GI absorption. March 2, 2015 [IRON SUCROSE REQUIREMENT CALCULATION FOR SEVERE ANEMIA] DPMU Anantapuramu | National Health Mission 1 Formula for calculating the required dose of Iron sucrose 2.4 X Pre-pregnancy Weight in Kgs X Hb% deficit{11-actual Hb%} in mgs Plus Iron required to replenish the iron stores = 500mg Prepregnancy Weight = 45 kgs . In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. Oral and parenteral products - see background option for oral products. ADMINISTER THE TEST DOSE AT A GRADUAL RATE OVER AT LEAST 30 SECONDS. Minor/Significance Unknown. Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Modify Therapy/Monitor Closely. Venofer (iron sucrose) Uses, Dosage, Side Effects - Drugs.com This drug is available at the lowest co-pay. Modify Therapy/Monitor Closely. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. The factor 2.4 comes about from the calculation that the total iron content of hemoglobin is 0.34%, the blood volume accounts for 7% . Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. restrictions. Monitor Closely (1)vitamin E decreases levels of iron sucrose by increasing hepatic clearance. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Introduction Uses Dosage Warnings Interactions Stability Introduction Hematinic agent; a polynuclear iron (III)-hydroxide sucrose complex. trientine, iron sucrose. Applies only to oral form of both agents. Minor/Significance Unknown. Available for Android and iOS devices. Avoid or Use Alternate Drug. iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. If these effects continue or worsen, tell your doctor.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Copyright(c) 2023 First Databank, Inc. 4. Assure stable intravenous access to avoid extravasation. iron sucrose, captopril. dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Minor/Significance Unknown. Do Not Copy, Distribute or otherwise Disseminate without express permission. 2 *Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with CKD. It should be recognized that iron storage may lag behind the appearance of normal blood morphology. US residents can call their local poison control center at 1-800-222-1222. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Med J Aust. calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Your list will be saved and can be edited at any time. VENOFER (IRON SUCROSE INJECTION,USP) 100mg ELEMENTAL IRON - DailyMed You are encouraged to report Adverse Drug Events to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. Official Journal of the International Society of Nephrology. Applies only to oral form of both agents. The dosage of Venofer is expressed in mg of elemental iron. Nutrition. Dose. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Intravenous iron therapy for patients with anemia Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Applies only to oral form of both agents. Use Caution/Monitor. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Avoid or Use Alternate Drug. commonly, these are generic drugs. 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator Formula for calculating the required dose of iron sucrose commonly, these are "non-preferred" brand drugs or specialty Iron Deficiency Anemia: Periodic hematologic determination (hemoglobin and hematocrit) is a simple and accurate technique for monitoring hematological response, and should be used as a guide in therapy. Pediatric Patients (2 Years of Age and Older). Iron Sucrose - SlideShare STORAGE: Consult the product instructions and your pharmacist for storage details. Applies only to oral form of both agents. Baloxavir may bind to polyvalent cations resulting in decreased absorption. 2. Our dosage calculator can help you with this as well. sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Minor/Significance Unknown. Ren Fail. Administer Venofer only intravenously by slow injection or by infusion. Do Not Copy, Distribute or otherwise Disseminate without express permission. Separate by 2 hr. Applies only to oral form of both agents. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. This may be helped by giving the medication more slowly or at a lower dose. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Only administer Feraheme as an intravenous infusion over at least 15 minutes and only when personnel and therapies are immediately available for the treatment of anaphylaxis and other hypersensitivity reactions. World J Gastroenterol; 16(22): 27202725. Avoid or Use Alternate Drug. Iron sucrose (Venofer) 100 mg/5 mL vial 200 - 300 mg given every 3-7 days 300 mg doses are given over 90 minutes 500 mg/dose. Minor/Significance Unknown. Applies only to oral form of both agents. 1. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. For all products, slow initial infusion is prudent; the patient is observed closely for infusion reactions. Iron Deficiency In Pregnancy Calculator, Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator. This health tool computes the required parenteral iron replacement dose for the iron deficit extracted from the patient weight and hemoglobin level from complete blood count test. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. The dosing for iron replacement treatment in pediatric patients with HDD-CKD has not been established. PDF Injectafer (ferric carboxymaltose injection) - Food and Drug Administration Use Caution/Monitor. 2000 Jan;22(1):39-43. Your doctor will do laboratory tests to monitor your response. Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. Each mL contains 20 mg of elemental iron. DICP. May increase risk of hypotension. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. PRECAUTIONS: Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. For liquid medications, also enter the value of the Medicine Concentration and choose . Use Caution/Monitor. Use Caution/Monitor. FERAHEME vs Venofer (iron sucrose) - Feraheme Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Venofer (iron sucrose) dose calculator | Calculosaurus.com Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). Use Caution/Monitor. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. Serious - Use Alternative (1)iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Anemia; 2015: 763576. If you log out, you will be required to enter your username and password the next time you visit. For iron maintenance treatment, administer Venofer, (2 years of age or older) with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in Human studies not conducted. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. If we don't have the calculator you need then tell us the details and we'll make it for you. Jacobs P, Dommisse J. Modify Therapy/Monitor Closely. Intravenous Injection - PRIOR TO THE FIRST INTRAVENOUS INFeD THERAPEUTIC DOSE, ADMINISTER AN INTRAVENOUS TEST DOSE OF 0.5 ML. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Drug Dosing in Obesity Reference Table - ClinCalc.com Interaction only with oral iron administration. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. Assessing new treatment options. Diagnosis and management of iron deficiency anaemia: a clinical update. Applies only to oral form of both agents. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . MISSED DOSE: It is important to get each dose of this medication as scheduled. Applies only to oral form of both agents. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). Max Dose. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. Feraheme does not contain antimicrobial preservatives. Use Caution/Monitor. Consult your doctor before breast-feeding. Applies only to oral form of both agents. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. All Rights Reserved. an automated flowchart approach. Avoid or Use Alternate Drug. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes.